Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1050	15q15.1	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B
Mouse	-	1052	2 E5	Bub1b	BUB1B, mitotic checkpoint serine/threonine kinase
Rat	-	1052	3q35	Bub1b	BUB1 mitotic checkpoint serine/threonine kinase B

Previous and Unofficial Names

Bub1A | BUBR1 | SSK1 | MAD3/BUB1-related protein kinase | Mitotic checkpoint kinase MAD3L | BUB1B, mitotic checkpoint serine/threonine kinase | BUB1B

Database Links
Alphafold	O60566 (Hs), Q9Z1S0 (Mm)
BRENDA	2.7.11.1
CATH/Gene3D	1.25.40.10
ChEMBL Target	CHEMBL4295998 (Hs)
Ensembl Gene	ENSG00000156970 (Hs), ENSMUSG00000040084 (Mm), ENSRNOG00000007906 (Rn)
Entrez Gene	701 (Hs), 12236 (Mm), 171576 (Rn)
Human Protein Atlas	ENSG00000156970 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:701 (Hs), mmu:12236 (Mm), rno:171576 (Rn)
OMIM	602860 (Hs)
Orphanet	ORPHA119101 (Hs)
Pharos	O60566 (Hs)
RefSeq Nucleotide	NM_001211 (Hs), NM_009773 (Mm), XM_342494 (Rn)
RefSeq Protein	NP_001202 (Hs), NP_033903 (Mm), XP_342495 (Rn)
UniProtKB	O60566 (Hs), Q9Z1S0 (Mm)
Wikipedia	BUB1B (Hs)

Selected 3D Structures
	Description:  Crystal structure of the N-terminal domain of BUBR1 PDB Id:  2WVI Resolution:  1.8Å Species:  Human References:  1

Enzyme Reaction
EC Number: 2.7.11.1

Clinically-Relevant Mutations and Pathophysiology
Disease:  Mosaic variegated aneuploidy syndrome 1; MVA1 Synonyms: Mosaic variegated aneuploidy syndrome [Orphanet: ORPHA1052] OMIM: 257300 Orphanet: ORPHA1052
Disease:  Premature chromatid separation trait OMIM: 176430