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Target id: 1893
Nomenclature: death receptor 6
Abbreviated Name: DR6
Systematic Nomenclature: TNFRSF21
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 655 | 6p12.3 | TNFRSF21 | TNF receptor superfamily member 21 | |
Mouse | 1 | 655 | 17 B3 | Tnfrsf21 | tumor necrosis factor receptor superfamily, member 21 | |
Rat | - | - | Tnfrsf21 | TNF receptor superfamily member 21 |
Previous and Unofficial Names |
tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily |
Database Links | |
Alphafold | O75509 (Hs), Q9EPU5 (Mm) |
Ensembl Gene | ENSG00000146072 (Hs), ENSMUSG00000023915 (Mm), ENSRNOG00000011517 (Rn) |
Entrez Gene | 27242 (Hs), 94185 (Mm), 316256 (Rn) |
Human Protein Atlas | ENSG00000146072 (Hs) |
KEGG Gene | hsa:27242 (Hs), mmu:94185 (Mm), rno:316256 (Rn) |
OMIM | 605732 (Hs) |
Pharos | O75509 (Hs) |
UniProtKB | O75509 (Hs), Q9EPU5 (Mm) |
Wikipedia | TNFRSF21 (Hs) |
Adaptor proteins (Human) |
TRADD |
Immunopharmacology Comments |
Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways. |
Immuno Process Associations | ||
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