Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	241	1p36.33	TNFRSF18	TNF receptor superfamily member 18
Mouse	1	228	4 E2	Tnfrsf18	tumor necrosis factor receptor superfamily, member 18
Rat	-	-		Tnfrsf18	TNF receptor superfamily member 18

Previous and Unofficial Names

activation-inducible TNFR family receptor | AITR | Glucocorticoid-induced TNFR-related protein | tumor necrosis factor receptor superfamily, member 18 | CD357 | tumor necrosis factor receptor superfamily

Database Links
Alphafold	Q9Y5U5 (Hs), O35714 (Mm)
ChEMBL Target	CHEMBL3712995 (Hs)
Ensembl Gene	ENSG00000186891 (Hs), ENSMUSG00000041954 (Mm), ENSRNOG00000022012 (Rn)
Entrez Gene	8784 (Hs), 21936 (Mm), 500598 (Rn)
Human Protein Atlas	ENSG00000186891 (Hs)
KEGG Gene	hsa:8784 (Hs), mmu:21936 (Mm), rno:500598 (Rn)
OMIM	603905 (Hs)
Pharos	Q9Y5U5 (Hs)
UniProtKB	Q9Y5U5 (Hs), O35714 (Mm)
Wikipedia	TNFRSF18 (Hs)

Natural/Endogenous Ligands
TL6 {Sp: Human}

Adaptor proteins (Human)

TRAF1, TRAF2, TRAF3, SIVA

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference TL6 {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

GITR appears to act as a co-stimulatory immune checkpoint molecule. T cell activation induces GITR expression. GITR inhibits the suppressive activity of Treg cells and promotes survival of Teff cells.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes GO:0002687 positive regulation of leukocyte migration IMP

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0002687 positive regulation of leukocyte migration IMP

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes GO:0005031 tumor necrosis factor receptor activity TAS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0002687 positive regulation of leukocyte migration IMP