Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	616	18q21.33	TNFRSF11A	TNF receptor superfamily member 11a
Mouse	1	625	1 E2.1	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Rat	-	-		Tnfrsf11a	TNF receptor superfamily member 11A

Previous and Unofficial Names

CD265 | ODFR | osteoclast differentiation factor receptor | TRANCE-R | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | tumor necrosis factor receptor superfamily, member 11a | tumor necrosis factor receptor superfamily member 11a | tumor necrosis factor receptor superfamily

Database Links
Alphafold	Q9Y6Q6 (Hs), O35305 (Mm)
Ensembl Gene	ENSG00000141655 (Hs), ENSMUSG00000026321 (Mm), ENSRNOG00000015615 (Rn)
Entrez Gene	8792 (Hs), 21934 (Mm), 498206 (Rn)
Human Protein Atlas	ENSG00000141655 (Hs)
KEGG Gene	hsa:8792 (Hs), mmu:21934 (Mm), rno:498206 (Rn)
OMIM	603499 (Hs)
Pharos	Q9Y6Q6 (Hs)
UniProtKB	Q9Y6Q6 (Hs), O35305 (Mm)
Wikipedia	TNFRSF11A (Hs)

Natural/Endogenous Ligands
RANK ligand {Sp: Human}

Adaptor proteins (Human)

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference RANK ligand {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

RANK is the receptor for RANK-ligand (RANKL). It is associated with immune cell function and lymph node development, in addition to bone remodeling and repair, thermal regulation, and mammary gland development. Signals to NF-κB and JNK via TRAF adaptor proteins.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes GO:0002548 monocyte chemotaxis NAS GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002250 adaptive immune response IMP

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002250 adaptive immune response IMP

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0048535 lymph node development IBA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 7 GO processes GO:0005031 tumor necrosis factor receptor activity ISS GO:0033209 tumor necrosis factor-mediated signaling pathway ISS GO:0034097 response to cytokine IMP GO:0034612 response to tumor necrosis factor ISS GO:0070555 response to interleukin-1 ISS GO:0071847 TNFSF11-mediated signaling pathway IMP GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IMP

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0002548 monocyte chemotaxis NAS