Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	937	1p31.3	ROR1	receptor tyrosine kinase like orphan receptor 1
Mouse	1	937	4 45.71 cM	Ror1	receptor tyrosine kinase-like orphan receptor 1
Rat	-	937	5q33	Ror1	receptor tyrosine kinase-like orphan receptor 1

Previous and Unofficial Names

NTRKR1 | neurotrophic tyrosine kinase, receptor-related 1

Database Links
Alphafold	Q01973 (Hs), Q9Z139 (Mm)
BRENDA	2.7.10.1
CATH/Gene3D	2.60.40.10, 1.10.2000.10
ChEMBL Target	CHEMBL4665585 (Hs), CHEMBL2176781 (Mm)
Ensembl Gene	ENSG00000185483 (Hs), ENSMUSG00000035305 (Mm), ENSRNOG00000029449 (Rn)
Entrez Gene	4919 (Hs), 26563 (Mm), 362550 (Rn)
Human Protein Atlas	ENSG00000185483 (Hs)
KEGG Enzyme	2.7.10.1
KEGG Gene	hsa:4919 (Hs), mmu:26563 (Mm), rno:362550 (Rn)
OMIM	602336 (Hs)
Pharos	Q01973 (Hs)
RefSeq Nucleotide	NM_001083592 (Hs), NM_013845 (Mm), NM_001108671 (Rn)
RefSeq Protein	NP_001077061 (Hs), NP_038873 (Mm), NP_001102141 (Rn)
UniProtKB	Q01973 (Hs), Q9Z139 (Mm)
Wikipedia	ROR1 (Hs)

Enzyme Reaction
EC Number: 2.7.10.1

General Comments

ROR1 is overexpressed by a variety of solid and hematological cancers (e.g. a subset of non-small cell lung cancer, triple-negative breast, pancreatic , and prostate cancers, B cell chronic lymphocytic leukemia and mantle cell lymphoma) and it is being investigated as a molecular target for therapeutic potential in ROR1 positive cancers. For example, VelosBio have an anti-ROR1 antibody drug conjugate (VLS-101) in Phase 2 trial as monotherapy for ROR1 positive cancers (NCT04504916). The toxic payload delivered by VLS-101 is the microtubule disrupting cytotoxin, monomethyl auristatin E (MMAE). In November 2020 Merck bought VelosBio. Juno Therapeutics (part of Bristol Myers Squibb) are taking a different route to target ROR1, with their ROR1-targeting (CAR) T-cells in clinical trial NCT02706392.