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Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 980 | 19q13.42 | NLRP7 | NLR family pyrin domain containing 7 | |
| Previous and Unofficial Names |
| CLR19.4 | NALP7 | NOD12 | PAN7 | PYPAF3 | NACHT, leucine rich repeat and PYD containing 7 | XXbac-BCX195L8.11-001 | HYDM | NLR family, pyrin domain containing 7 |
| Database Links |
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| Alphafold | Q8WX94 (Hs) |
| Ensembl Gene | ENSG00000167634 (Hs) |
| Entrez Gene | 199713 (Hs) |
| Human Protein Atlas | ENSG00000167634 (Hs) |
| KEGG Gene | hsa:199713 (Hs) |
| OMIM | 609661 (Hs) |
| Pharos | Q8WX94 (Hs) |
| UniProtKB | Q8WX94 (Hs) |
| Wikipedia | NLRP7 (Hs) |
| Immunopharmacology Comments |
| NLRP7 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB. |
| Physiological Functions Comments | |
| Involved in embyronic development and regulation of interleukin 1β. |
| Clinically-Relevant Mutations and Pathophysiology
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