Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	975	11q23.3	NLRX1	NLR family member X1
Mouse	-	975	9 A5.2	Nlrx1	NLR family member X1
Rat	-	973	8q22	Nlrx1	NLR family member X1

Previous and Unofficial Names

CLR11.3 | NOD9 | NOD-like receptor X1 | NLR family member X1 | DLNB26 | NOD26 | NOD5

Database Links
Alphafold	Q86UT6 (Hs), Q3TL44 (Mm), Q5FVQ8 (Rn)
Ensembl Gene	ENSG00000160703 (Hs), ENSMUSG00000032109 (Mm), ENSRNOG00000052386 (Rn)
Entrez Gene	79671 (Hs), 270151 (Mm), 315599 (Rn)
Human Protein Atlas	ENSG00000160703 (Hs)
KEGG Gene	hsa:79671 (Hs), mmu:270151 (Mm), rno:315599 (Rn)
OMIM	611947 (Hs)
Pharos	Q86UT6 (Hs)
UniProtKB	Q86UT6 (Hs), Q3TL44 (Mm), Q5FVQ8 (Rn)
Wikipedia	NLRX1 (Hs)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference amelenodor Hs Activation 4.5 pKd 1 ⤷ pKd 4.5 (Kd 3x10-5 M) [1] Description: Dissociation constsnt determined by surface plasmon resonance

Immunopharmacology Comments

NLRX1 is an intracellular pattern recognition receptor that plays a role in host immunity to certain bacterial infections.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Physiological Functions Comments

Involved in negative regulation of inflammatory signalling.