Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	811	4p14	TLR10	toll like receptor 10
Rat	-	-	14p11	Tlr10	toll-like receptor 10

Previous and Unofficial Names

toll-like receptor 10 | CD290 | UNQ315/PRO358

Database Links
Alphafold	Q9BXR5 (Hs)
CATH/Gene3D	3.80.10.10, 3.40.50.10140
Ensembl Gene	ENSG00000174123 (Hs), ENSRNOG00000067138 (Rn)
Entrez Gene	81793 (Hs), 305355 (Rn)
Human Protein Atlas	ENSG00000174123 (Hs)
KEGG Gene	hsa:81793 (Hs), rno:305355 (Rn)
OMIM	606270 (Hs)
Pharos	Q9BXR5 (Hs)
UniProtKB	Q9BXR5 (Hs)
Wikipedia	TLR10 (Hs)

Immunopharmacology Comments

To date, ligands and biological functions of human TLR10 remain unclear. However, evidence suggests it plays a modulatory role with predominantly inhibitory (anti-inflammatory) effects [1].

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 6 GO processes GO:0002224 toll-like receptor signaling pathway IBA GO:0006954 inflammatory response IBA GO:0045087 innate immune response IC click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034166 toll-like receptor 10 signaling pathway IEA GO:0050729 positive regulation of inflammatory response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002224 toll-like receptor signaling pathway IBA click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034166 toll-like receptor 10 signaling pathway IEA GO:0050729 positive regulation of inflammatory response IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0002224 toll-like receptor signaling pathway IBA click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034166 toll-like receptor 10 signaling pathway IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0001817 regulation of cytokine production IEA

Physiological Functions Comments

Detection of influenza and listeria.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to Disease Ontology: DOID:2841 OMIM: 600807