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natriuretic peptide receptor 3

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Target id: 1749

Nomenclature: natriuretic peptide receptor 3

Abbreviated Name: NPR-C

Family: Transmembrane guanylyl cyclases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 541 5p13.3 NPR3 natriuretic peptide receptor 3
Mouse 1 536 15 5.83 cM Npr3 natriuretic peptide receptor 3
Rat 1 535 2q16 Npr3 natriuretic peptide receptor 3
Previous and Unofficial Names Click here for help
ANP-C | ANP-CR | ANPR-C | Atrial natriuretic peptide clearence receptor 3 | atrial natriuretic peptide receptor 3 | atrial natriuretic peptide receptor type C | GUCY2B | lgj | longjohn | natriuretic peptide receptor-C | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | Nppc receptor | NPR3
Database Links Click here for help
Alphafold P17342 (Hs), P70180 (Mm), P41740 (Rn)
ChEMBL Target CHEMBL2247 (Hs), CHEMBL4711 (Mm)
Ensembl Gene ENSG00000113389 (Hs), ENSMUSG00000022206 (Mm), ENSRNOG00000019184 (Rn)
Entrez Gene 4883 (Hs), 18162 (Mm), 25339 (Rn)
Human Protein Atlas ENSG00000113389 (Hs)
KEGG Gene hsa:4883 (Hs), mmu:18162 (Mm), rno:25339 (Rn)
OMIM 108962 (Hs)
Pharos P17342 (Hs)
UniProtKB P17342 (Hs), P70180 (Mm), P41740 (Rn)
Wikipedia NPR3 (Hs)
Natural/Endogenous Ligands Click here for help
osteocrin {Sp: Human}
Potency order (Human)
atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860)  [5]

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PL-3994 Peptide Click here for species-specific activity table Hs Agonist 8.1 pKi 1
⤷ pKi 8.1 (Ki 7x10-9 M) [1]
cANF4-23 Peptide Hs Agonist - - 3
⤷ [3]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AP811 Peptide Hs Binding 9.3 pKi 6
⤷ pKi 9.3 (Ki 5x10-10 M) [6]
M372049 Peptide Hs Antagonist - - 2
⤷ [2]
osteocrin {Sp: Human} Peptide Ligand is endogenous in the given species Hs Antagonist - - 4
⤷ [4]
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]ANP (human) Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs - - -
⤷

References

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1. Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW et al.. (2013) In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther, 26 (2): 229-38. [PMID:23154072]

2. Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A. (2004) Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation, 110 (10): 1231-5. [PMID:15337698]

3. Maack T, Suzuki M, Almeida FA, Nussenzveig D, Scarborough RM, McEnroe GA, Lewicki JA. (1987) Physiological role of silent receptors of atrial natriuretic factor. Science, 238 (4827): 675-8. [PMID:2823385]

4. Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C. (2007) Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. J Biol Chem, 282 (50): 36454-62. [PMID:17951249]

5. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]

6. Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR, Dantzman CL, Edwards PD, Jacobs RT et al.. (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett, 10 (17): 1949-52. [PMID:10987424]

Contributors

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