Top ▲

Interleukin 17 receptor A

Click here for help

Target id: 1738

Nomenclature: Interleukin 17 receptor A

Family: IL-17 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-17 receptor
Interleukin-25 receptor
Interleukin-17C receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 866 22q11.1 IL17RA interleukin 17 receptor A
Mouse 1 864 6 56.95 cM Il17ra interleukin 17 receptor A
Rat - - Il17ra interleukin 17 receptor A
Previous and Unofficial Names Click here for help
CD217 | VDw217 | Interleukin-17 α receptor
Database Links Click here for help
Alphafold Q96F46 (Hs), Q60943 (Mm)
ChEMBL Target CHEMBL3580485 (Hs)
Ensembl Gene ENSG00000177663 (Hs), ENSMUSG00000002897 (Mm), ENSRNOG00000011153 (Rn)
Entrez Gene 23765 (Hs), 16172 (Mm), 312679 (Rn)
Human Protein Atlas ENSG00000177663 (Hs)
KEGG Gene hsa:23765 (Hs), mmu:16172 (Mm), rno:312679 (Rn)
OMIM 605461 (Hs)
Pharos Q96F46 (Hs)
UniProtKB Q96F46 (Hs), Q60943 (Mm)
Wikipedia IL17RA (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
brodalumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 9.2 pKd 1
⤷ pKd 9.2 (Kd 6.9x10-10 M) [1]
Immunopharmacology Comments
This protein is a common subunit shared by the heterodimeric receptors for interleukins 17 (A, B , C and F) and 25.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 8 GO processes
GO:0030368 interleukin-17 receptor activity IDA
GO:0032747 positive regulation of interleukin-23 production IDA
GO:0032755 positive regulation of interleukin-6 production IMP
GO:0097400 interleukin-17-mediated signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
click arrow to show/hide IEA associations
GO:0032736 positive regulation of interleukin-13 production IEA
GO:0032754 positive regulation of interleukin-5 production IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes, IEA only
GO:0050729 positive regulation of inflammatory response IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
GO:0071621 granulocyte chemotaxis IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0050729 positive regulation of inflammatory response IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes, IEA only
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
click arrow to show/hide IEA associations
GO:0071621 granulocyte chemotaxis IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0072538 T-helper 17 type immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0072538 T-helper 17 type immune response IEA

References

Show »

1. Tocker J, Mehlin C, Lim AC. (2010) Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto. Patent number: US7767206. Assignee: Amgen Inc.. Priority date: 02/10/2006. Publication date: 03/08/2010.

How to cite this page

IL-17 receptor family: Interleukin 17 receptor A. Last modified on 07/04/2017. Accessed on 10/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1738.