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Interleukin 1 receptor, type I

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Target id: 1734

Nomenclature: Interleukin 1 receptor, type I

Family: Immunoglobulin-like family of IL-1 receptors

Contents:

Quaternary Structure: Complexes
Interleukin-1 receptor, type I
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 569 2q11.2-q12.1 IL1R1 interleukin 1 receptor type 1
Mouse 1 576 1 18.81 cM Il1r1 interleukin 1 receptor, type I
Rat 1 576 9q22 Il1r1 interleukin 1 receptor type 1
Previous and Unofficial Names Click here for help
CD121A | IL1RA | CD121 antigen-like family member A | IL-1R-alpha | interleukin 1 beta receptor type 1 short transmembrane form | interleukin 1 beta receptor type 1 soluble form | interleukin 1 bete receptor type 1 long transmembrane form | interleukin-1 receptor alpha | interleukin 1 receptor
Database Links Click here for help
Alphafold P14778 (Hs), P13504 (Mm), Q02955 (Rn)
CATH/Gene3D 3.40.50.10140, 2.60.40.10
ChEMBL Target CHEMBL1959 (Hs), CHEMBL2189148 (Mm)
DrugBank Target P14778 (Hs)
Ensembl Gene ENSG00000115594 (Hs), ENSMUSG00000026072 (Mm), ENSRNOG00000014504 (Rn)
Entrez Gene 3554 (Hs), 16177 (Mm), 25663 (Rn)
Human Protein Atlas ENSG00000115594 (Hs)
KEGG Gene hsa:3554 (Hs), mmu:16177 (Mm), rno:25663 (Rn)
OMIM 147810 (Hs)
Pharos P14778 (Hs)
UniProtKB P14778 (Hs), P13504 (Mm), Q02955 (Rn)
Wikipedia IL1R1 (Hs)
Immunopharmacology Comments
This is one of the subunits of the functional IL-1 receptor type I heterodimer.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0004908 interleukin-1 receptor activity IDA
GO:0004909 interleukin-1, type I, activating receptor activity TAS
GO:0032729 positive regulation of type II interferon production IDA
GO:0070498 interleukin-1-mediated signaling pathway IDA
GO:0070555 response to interleukin-1 IDA
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
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GO:2000661 positive regulation of interleukin-1-mediated signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0050727 regulation of inflammatory response IBA
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:2000391 positive regulation of neutrophil extravasation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0050727 regulation of inflammatory response IBA
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:2000391 positive regulation of neutrophil extravasation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:2000391 positive regulation of neutrophil extravasation IEA

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type I. Last modified on 22/03/2017. Accessed on 10/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1734.