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TAAR9

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Target id: 173

Nomenclature: TAAR9

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: pseudogene in some individuals
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 348 6q23.2 TAAR9 trace amine associated receptor 9
Mouse 7 348 10 A4 Taar9 trace amine-associated receptor 9
Rat 7 338 1p12 Taar9 trace amine-associated receptor 9
Previous and Unofficial Names Click here for help
TRAR3 | trace amine receptor 3 | trace amine receptor 9 | trace amine associated receptor 9 (gene/pseudogene)
Database Links Click here for help
Specialist databases
GPCRdb taar9_human (Hs), taar9_mouse (Mm), taar9_rat (Rn)
Other databases
Alphafold Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
ChEMBL Target CHEMBL4523911 (Hs)
Ensembl Gene ENSG00000237110 (Hs), ENSMUSG00000037424 (Mm), ENSRNOG00000026096 (Rn)
Entrez Gene 134860 (Hs), 503558 (Mm), 319107 (Rn)
Human Protein Atlas ENSG00000237110 (Hs)
KEGG Gene hsa:134860 (Hs), mmu:503558 (Mm), rno:319107 (Rn)
OMIM 608282 (Hs)
Pharos Q96RI9 (Hs)
RefSeq Nucleotide NM_175057 (Hs), NM_001010831 (Mm), NM_175602 (Rn)
RefSeq Protein NP_778227 (Hs), NP_001010831 (Mm), NP_783192 (Rn)
UniProtKB Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
Wikipedia TAAR9 (Hs)
Tissue Distribution Click here for help
Pituitary gland, skeletal muscle
Species:  Human
Technique:  Northern blot
References:  4
Kidney
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  3
Tissue Distribution Comments
No expression of TAAR9 was detected by RT-PCR in the Grueneberg ganglion [2]. TAAR9 expression was not detected by Northern blot analysis in thalamus, amygdala, midbrain, hippocampus, putamen, caudate, frontal cortex, pons, prostate, stomach, heart, bladder, small intestine, colon or uterus [4].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A278T
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 1|4|2|5
Minor allele count:  A=0.032/69
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs9389004
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S335L
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 11|1
Minor allele count:  T=0.028/60
SNP accession:  rs61741985
Validation:  1000 Genomes, Frequency, Cluster
General Comments
TAAR9 appears to be functional in most individuals but has a polymorphic premature stop codon at amino acid 61 (rs2842899) with an allele frequency of 10–30% in different populations [4].

References

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1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA, 98 (16): 8966-71. [PMID:11459929]

2. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem Senses, 32 (6): 623-31. [PMID:17556730]

3. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

4. Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF. (2003) Discovery of a null mutation in a human trace amine receptor gene. Genomics, 82: 531-536. [PMID:14559210]

Contributors

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