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Growth hormone receptor

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Target id: 1720

Nomenclature: Growth hormone receptor

Family: Prolactin receptor family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 638 5p13.1-p12 GHR growth hormone receptor
Mouse 1 650 15 1.84 cM Ghr growth hormone receptor
Rat 1 638 2q16 Ghr growth hormone receptor
Previous and Unofficial Names Click here for help
GH-binding protein | GHBP | GH receptor | somatotropin receptor
Database Links Click here for help
Alphafold P10912 (Hs), P16882 (Mm), P16310 (Rn)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL1976 (Hs)
DrugBank Target P10912 (Hs)
Ensembl Gene ENSG00000112964 (Hs), ENSMUSG00000055737 (Mm), ENSRNOG00000015654 (Rn)
Entrez Gene 2690 (Hs), 14600 (Mm), 25235 (Rn)
Human Protein Atlas ENSG00000112964 (Hs)
KEGG Gene hsa:2690 (Hs), mmu:14600 (Mm), rno:25235 (Rn)
OMIM 600946 (Hs)
Orphanet ORPHA122095 (Hs)
Pharos P10912 (Hs)
UniProtKB P10912 (Hs), P16882 (Mm), P16310 (Rn)
Wikipedia GHR (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human growth hormone bound to the growth hormone receptor
PDB Id:  1A22
Ligand:  growth hormone 1
Resolution:  2.6Å
Species:  Human
References:  1
Natural/Endogenous Ligands Click here for help
growth hormone 1 {Sp: Human}
growth hormone 2 {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
growth hormone 1 {Sp: Human} Peptide Approved drug Primary target of this compound Ligand is endogenous in the given species Hs Agonist 9.0 pKd 2
⤷ pKd 9.0 (Kd 9.1x10-10 M) [2]
Description: Binding affinity of recombinant GH1 (somatropin), to immobilised hGHR by SPR
somatrogon Peptide Approved drug Rn Agonist 8.3 pKd 2
⤷ pKd 8.3 (Kd 5.12x10-9 M) [2]
somatrogon Peptide Approved drug Hs Agonist 8.2 pKd 2
⤷ pKd 8.2 (Kd 6.38x10-9 M) [2]
Description: Binding affinity determined by SPR assay
somatrogon Peptide Approved drug Monkey Agonist 7.9 pKd 2
⤷ pKd 7.9 (Kd 1.146x10-8 M) [2]
growth hormone 2 {Sp: Human} Peptide Ligand is endogenous in the given species Hs Agonist - -
⤷
View species-specific agonist tables
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
pegvisomant Peptide Approved drug Primary target of this compound Hs Antagonist - - 3
⤷ [3]
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  Cytokine production & signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Growth hormone insensitivity, partial; GHIP
Synonyms: Short stature due to partial GHR deficiency [Orphanet: ORPHA314802]
OMIM: 604271
Orphanet: ORPHA314802
Disease:  Hypercholesterolemia, familial
Disease Ontology: DOID:13810
OMIM: 143890
Disease:  Laron syndrome
Disease Ontology: DOID:9521
OMIM: 262500
Orphanet: ORPHA633

References

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1. Clackson T, Ultsch MH, Wells JA, de Vos AM. (1998) Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J Mol Biol, 277 (5): 1111-28. [PMID:9571026]

2. Hershkovitz O, Bar-Ilan A, Guy R, Felikman Y, Moschcovich L, Hwa V, Rosenfeld RG, Fima E, Hart G. (2016) In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone. Mol Pharm, 13 (2): 631-9. [PMID:26713839]

3. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML et al.. (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med, 342 (16): 1171-7. [PMID:10770982]

How to cite this page

Prolactin receptor family: Growth hormone receptor. Last modified on 30/05/2022. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1720.