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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 380 | Xq23 | IL13RA2 | interleukin 13 receptor subunit alpha 2 | |
Mouse | 1 | 383 | X 68.46 cM | Il13ra2 | interleukin 13 receptor, alpha 2 | |
Rat | 1 | 385 | Xq34 | Il13ra2 | interleukin 13 receptor subunit alpha 2 |
Previous and Unofficial Names |
interleukin 13 receptor | cancer/testis antigen 19 | CD213a2 | CT19 | IL13BP | IL-13RA2 | IL-13 receptor alpha-2 | IL-13R subunit alpha-2 |
Database Links | |
Alphafold | Q14627 (Hs), O88786 (Mm), Q8VHK6 (Rn) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL3713941 (Hs) |
Ensembl Gene | ENSG00000123496 (Hs), ENSMUSG00000031289 (Mm), ENSRNOG00000032973 (Rn) |
Entrez Gene | 3598 (Hs), 16165 (Mm), 171060 (Rn) |
Human Protein Atlas | ENSG00000123496 (Hs) |
KEGG Gene | hsa:3598 (Hs), mmu:16165 (Mm), rno:171060 (Rn) |
OMIM | 300130 (Hs) |
Pharos | Q14627 (Hs) |
UniProtKB | Q14627 (Hs), O88786 (Mm), Q8VHK6 (Rn) |
Wikipedia | IL13RA2 (Hs) |
Immunopharmacology Comments |
Interleukin 13 receptor, α2 acts as a high affinity decoy receptor for interleukin 13 that sequesters the ligand away from IL13Rα1 and is involved in down-regulating IL-13 responses in vivo. IL13ra2 null mice exhibit enhanced IL-13 responses [4]. Increased expression of IL13Rα2 has been reported to promote tumor progression in glioma and other tumor models, and its expression is a prognostic marker for glioma malignancy grade and for poor patient survival [1,3]. This receptor has not been detected on normal brian tissue, making IL13Rα2 a novel selective drug target that has been intensively investigated for the treatment of glioblastoma, with several immunotherapeutic candidates advancing to clinical trial (reviewed in [2]). |
Immuno Process Associations | ||
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1. Debinski W, Gibo DM, Hulet SW, Connor JR, Gillespie GY. (1999) Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin Cancer Res, 5 (5): 985-90. [PMID:10353730]
2. Sengupta S, Thaci B, Crawford AC, Sampath P. (2014) Interleukin-13 receptor alpha 2-targeted glioblastoma immunotherapy. Biomed Res Int, 2014: 952128. [PMID:25247196]
3. Tu M, Wange W, Cai L, Zhu P, Gao Z, Zheng W. (2016) IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tumour Biol, 37 (11): 14701-14709. [PMID:27623944]
4. Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ et al.. (2003) Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med, 197 (6): 703-9. [PMID:12642602]
IL-2 receptor family: Interleukin 13 receptor, α2. Last modified on 10/04/2017. Accessed on 13/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1701.