Quaternary Structure: Complexes

Interleukin-2 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	272	10p15.1	IL2RA	interleukin 2 receptor subunit alpha
Mouse	1	268	2 8.91 cM	Il2ra	interleukin 2 receptor, alpha chain
Rat	1	267	17q12.2	Il2ra	interleukin 2 receptor subunit alpha

Previous and Unofficial Names

CD25 | TAC antigen | IL2RAC | IL-2R alpha chain | Ly-43 | interleukin 2 receptor

Database Links
Alphafold	P01589 (Hs), P01590 (Mm), P26897 (Rn)
ChEMBL Target	CHEMBL1778 (Hs), CHEMBL3287 (Mm)
DrugBank Target	P01589 (Hs)
Ensembl Gene	ENSG00000134460 (Hs), ENSMUSG00000026770 (Mm), ENSRNOG00000047647 (Rn)
Entrez Gene	3559 (Hs), 16184 (Mm), 25704 (Rn)
Human Protein Atlas	ENSG00000134460 (Hs)
KEGG Gene	hsa:3559 (Hs), mmu:16184 (Mm), rno:25704 (Rn)
OMIM	147730 (Hs)
Pharos	P01589 (Hs)
UniProtKB	P01589 (Hs), P01590 (Mm), P26897 (Rn)
Wikipedia	IL2RA (Hs)

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Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference daclizumab Hs Binding >8.0 pKd 1 ⤷ pKd >8.0 (Kd <1x10-8 M) [1] basiliximab Hs Binding - - ⤷

Immunopharmacology Comments

IL2RA is a ligand binding component of the IL-2R complex. This subunit is the molecular target of the approved biologics daclizumab (including daclizumab beta) and basiliximab. Another anti-CD25 mAb, inolimomab, has received orphan drug designation from the EMA, for the treatment of graft-versus-host disease. Phase 3 findings for this drug and indication are reported in [2], the major conclusion being that the primary end point for the trial was not met (no statistical difference between the inolimomab and normal standard of care arms of the study).

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  T cell (activation)

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling