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TAAR4P

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Target id: 169

Nomenclature: TAAR4P

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: pseudogene in man but functional in rodents
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 6q23.2 TAAR4P trace amine associated receptor 4, pseudogene
Mouse 7 347 10 A4 Taar4 trace amine-associated receptor 4
Rat 7 347 1p12 Taar4 trace amine-associated receptor 4
Previous and Unofficial Names Click here for help
trace amine receptor 4 | trace amine-associated receptor 4
Database Links Click here for help
Specialist databases
GPCRdb taar4_mouse (Mm), taar4_rat (Rn)
Other databases
Alphafold Q5QD15 (Mm), Q923Y7 (Rn)
Ensembl Gene ENSG00000237449 (Hs), ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
Entrez Gene 503612 (Hs), 209513 (Mm), 294122 (Rn)
Human Protein Atlas ENSG00000237449 (Hs)
KEGG Gene hsa:503612 (Hs), mmu:209513 (Mm), rno:294122 (Rn)
RefSeq Nucleotide NM_001008499 (Mm), NM_175583 (Rn)
RefSeq Protein NP_001008499 (Mm), NP_783173 (Rn)
UniProtKB Q5QD15 (Mm), Q923Y7 (Rn)
Wikipedia TAAR4P (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
β-phenylethylamine Small molecule or natural product Click here for species-specific activity table Mm Agonist 6.0 pEC50 1
⤷ pEC50 6.0 (EC50 1x10-6 M) [1]
xylometazoline Small molecule or natural product Approved drug Mm Full agonist - - 3
⤷ [3]
β-phenylethylamine Small molecule or natural product Click here for species-specific activity table Rn Partial agonist - - 3
⤷ [3]
naphazoline Small molecule or natural product Approved drug Mm Agonist - - 3
⤷ [3]
naphazoline Small molecule or natural product Approved drug Rn Partial agonist - - 3
⤷ [3]
View species-specific agonist tables
Agonist Comments
Agonist activity for β-phenylethylamine, naphazoline and xylometazoline was measured by CRE-SEAP reporter gene assay [3].
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family Adenylyl cyclase stimulation
References:  3
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
The compound β-phenylethylamine is elevated in urine in stress responses in rodents and humans, suggesting a role for TAAR4 in stress and social cues [1-2].

References

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1. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

2. Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP. (2009) International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol Rev, 61 (1): 1-8. [PMID:19325074]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

Contributors

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