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MMP25

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Target id: 1647

Nomenclature: MMP25

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 562 16p13.3 MMP25 matrix metallopeptidase 25
Mouse 1 615 17 A3.3 Mmp25 matrix metallopeptidase 25
Rat - - 10q12 Mmp25 matrix metallopeptidase 25
Previous and Unofficial Names Click here for help
leukolysin | MT6-MMP | MMP20 | MMPL1
Database Links Click here for help
Specialist databases
MEROPS M10.024 (Hs)
Other databases
Alphafold Q9NPA2 (Hs), Q3U435 (Mm)
BRENDA 3.4.24.-
CATH/Gene3D 2.110.10.10, 3.40.390.10
ChEMBL Target CHEMBL1795103 (Hs)
DrugBank Target Q9NPA2 (Hs)
Ensembl Gene ENSG00000008516 (Hs), ENSMUSG00000023903 (Mm), ENSRNOG00000071032 (Rn)
Entrez Gene 64386 (Hs), 240047 (Mm)
Human Protein Atlas ENSG00000008516 (Hs)
KEGG Enzyme 3.4.24.-
KEGG Gene hsa:64386 (Hs), mmu:240047 (Mm)
OMIM 608482 (Hs)
Pharos Q9NPA2 (Hs)
RefSeq Nucleotide NM_022468 (Hs), NM_001033339 (Mm)
RefSeq Protein NP_071913 (Hs), NP_001028511 (Mm)
UniProtKB Q9NPA2 (Hs), Q3U435 (Mm)
Wikipedia MMP25 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CGS-27023A Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.8 pIC50 1
⤷ pIC50 8.8 (IC50 1.5x10-9 M) [1]

References

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1. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]

How to cite this page

M10: Matrix metallopeptidase: MMP25. Last modified on 16/03/2017. Accessed on 01/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1647.