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Target id: 1606
Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1
Family: M28: Aminopeptidase Y
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 750 | 11p11.12 | FOLH1 | folate hydrolase 1 | |
Mouse | 1 | 752 | 7 D3 | Folh1 | folate hydrolase 1 | |
Rat | 1 | 752 | 1q32 | Folh1 | folate hydrolase 1 |
Database Links ![]() |
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Specialist databases | |
MEROPS | M28.010 (Hs) |
Other databases | |
Alphafold | Q04609 (Hs), O35409 (Mm), P70627 (Rn) |
BRENDA | 3.4.17.21 |
CATH/Gene3D | 1.20.930.40 |
ChEMBL Target | CHEMBL1892 (Hs), CHEMBL5098 (Rn) |
DrugBank Target | Q04609 (Hs) |
Ensembl Gene | ENSG00000086205 (Hs), ENSMUSG00000001773 (Mm), ENSRNOG00000013770 (Rn) |
Entrez Gene | 2346 (Hs), 53320 (Mm), 85309 (Rn) |
Human Protein Atlas | ENSG00000086205 (Hs) |
KEGG Enzyme | 3.4.17.21 |
KEGG Gene | hsa:2346 (Hs), mmu:53320 (Mm), rno:85309 (Rn) |
OMIM | 600934 (Hs) |
Pharos | Q04609 (Hs) |
RefSeq Nucleotide | NM_001193473 (Hs), NM_004476 (Hs), NM_001014986 (Hs), NM_001193471 (Hs), NM_001193472 (Hs), NM_001159706 (Mm), NM_016770 (Mm), NM_057185 (Rn) |
RefSeq Protein | NP_001180401 (Hs), NP_001180402 (Hs), NP_004467 (Hs), NP_001180400 (Hs), NP_001014986 (Hs), NP_058050 (Mm), NP_001153178 (Mm), NP_476533 (Rn) |
UniProtKB | Q04609 (Hs), O35409 (Mm), P70627 (Rn) |
Wikipedia | FOLH1 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Benešová M, Schäfer M, Bauder-Wüst U, Afshar-Oromieh A, Kratochwil C, Mier W, Haberkorn U, Kopka K, Eder M. (2015) Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer. J Nucl Med, 56 (6): 914-20. [PMID:25883127]
2. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem, 47 (7): 1729-38. [PMID:15027864]
M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 02/05/2022. Accessed on 15/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1606.