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Puromycin-sensitive aminopeptidase

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Target id: 1575

Nomenclature: Puromycin-sensitive aminopeptidase

Family: M1: Aminopeptidase N

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 919 17q21.32 NPEPPS aminopeptidase puromycin sensitive
Mouse - 920 11 60.95 cM Npepps aminopeptidase puromycin sensitive
Rat - - 10q31 Npepps aminopeptidase puromycin sensitive
Previous and Unofficial Names Click here for help
metalloproteinase MP100 | PSA
Database Links Click here for help
Specialist databases
MEROPS M01.010 (Hs)
Other databases
Alphafold P55786 (Hs), Q11011 (Mm)
BRENDA 3.4.11.14
ChEMBL Target CHEMBL2264 (Hs)
Ensembl Gene ENSG00000141279 (Hs), ENSMUSG00000001441 (Mm), ENSRNOG00000023095 (Rn)
Entrez Gene 9520 (Hs), 19155 (Mm), 50558 (Rn)
Human Protein Atlas ENSG00000141279 (Hs)
KEGG Enzyme 3.4.11.14
KEGG Gene hsa:9520 (Hs), mmu:19155 (Mm), rno:50558 (Rn)
OMIM 606793 (Hs)
Pharos P55786 (Hs)
RefSeq Nucleotide NM_006310 (Hs), NM_008942 (Mm)
RefSeq Protein NP_006301 (Hs), NP_032968 (Mm)
UniProtKB P55786 (Hs), Q11011 (Mm)
Wikipedia NPEPPS (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.11.14

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
puromycin Small molecule or natural product Ligand has a PDB structure Hs Inhibition 5.6 pIC50 1
⤷ pIC50 5.6 (IC50 2.45x10-6 M) [1]
ANTAQ Small molecule or natural product Primary target of this compound Hs Inhibition 5.5 pIC50 2
⤷ pIC50 5.5 (IC50 2.9x10-6 M) [2]
Immuno Process Associations
Immuno Process:  Cellular signalling

References

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1. Aeluri R, Ganji RJ, Marapaka AK, Pillalamarri V, Alla M, Addlagatta A. (2015) Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase. Eur J Med Chem, 106: 26-33. [PMID:26513642]

2. Kakuta H, Koiso Y, Nagasawa K, Hashimoto Y. (2003) Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett, 13 (1): 83-6. [PMID:12467622]

How to cite this page

M1: Aminopeptidase N: Puromycin-sensitive aminopeptidase. Last modified on 08/04/2024. Accessed on 19/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1575.