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Leucine aminopeptidase 3

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Target id: 1569

Nomenclature: Leucine aminopeptidase 3

Family: M17: Leucyl aminopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 4p15.32 LAP3 leucine aminopeptidase 3
Mouse - 519 5 24.98 cM Lap3 leucine aminopeptidase 3
Rat - 519 14q11 Lap3 leucine aminopeptidase 3
Previous and Unofficial Names Click here for help
LAP | LAPEP | peptidase S | cytosol aminopeptidase | LAP-3 | leucine aminopeptidase 3 | proline aminopeptidase | prolyl aminopeptidase | Pep7 | PEPS
Database Links Click here for help
Specialist databases
MEROPS M17.001 (Hs)
Other databases
Alphafold P28838 (Hs), Q9CPY7 (Mm), Q68FS4 (Rn)
BRENDA 3.4.11.1
ChEMBL Target CHEMBL3965 (Hs)
Ensembl Gene ENSG00000002549 (Hs), ENSMUSG00000039682 (Mm), ENSRNOG00000003289 (Rn)
Entrez Gene 51056 (Hs), 66988 (Mm), 289668 (Rn)
Human Protein Atlas ENSG00000002549 (Hs)
KEGG Enzyme 3.4.11.1
KEGG Gene hsa:51056 (Hs), mmu:66988 (Mm), rno:289668 (Rn)
OMIM 170250 (Hs)
Pharos P28838 (Hs)
RefSeq Nucleotide NM_015907 (Hs), NM_024434 (Mm), NM_001011910 (Rn)
RefSeq Protein NP_056991 (Hs), NP_077754 (Mm), NP_001011910 (Rn)
UniProtKB P28838 (Hs), Q9CPY7 (Mm), Q68FS4 (Rn)
Wikipedia LAP3 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bestatin Small molecule or natural product Bt Inhibition 9.2 pKi 1-2
⤷ pKi 9.2 (Ki 6x10-10 M) [1-2]

References

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1. Grembecka J, Mucha A, Cierpicki T, Kafarski P. (2003) The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity. J Med Chem, 46 (13): 2641-55. [PMID:12801228]

2. Taylor A, Peltier CZ, Torre FJ, Hakamian N. (1993) Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor. Biochemistry, 32 (3): 784-90. [PMID:8422382]

How to cite this page

M17: Leucyl aminopeptidase: Leucine aminopeptidase 3. Last modified on 22/07/2015. Accessed on 26/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1569.