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CDC42 binding protein kinase gamma

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Target id: 1506

Nomenclature: CDC42 binding protein kinase gamma

Abbreviated Name: DMPK2

Family: GEK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1551 11q13.1 CDC42BPG CDC42 binding protein kinase gamma
Mouse - 1551 19 A Cdc42bpg CDC42 binding protein kinase gamma
Rat - 1551 1q43 Cdc42bpg CDC42 binding protein kinase gamma
Previous and Unofficial Names Click here for help
HSMDPKIN | kappa-200 | MRCKγ | MRCKgamma | CDC42 binding protein kinase gamma (DMPK-like) | serine/threonine-protein kinase MRCK gamma | CDC42-binding protein kinase gamma | DMPK-like gamma | myotonic dystrophy protein kinase-like alpha | myotonic dystrophy protein kinase-like gamma | Myotonic dystrophy kinase-related CDC42 binding protein kinase γ | myotonic dystrophy kinase-related CDC42-binding kinase gamma
Database Links Click here for help
Alphafold Q6DT37 (Hs), Q80UW5 (Mm)
BRENDA 2.7.11.1
CATH/Gene3D 2.30.29.30
ChEMBL Target CHEMBL5615 (Hs)
Ensembl Gene ENSG00000171219 (Hs), ENSMUSG00000024769 (Mm), ENSRNOG00000027456 (Rn)
Entrez Gene 55561 (Hs), 240505 (Mm), 293693 (Rn)
Human Protein Atlas ENSG00000171219 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:55561 (Hs), mmu:240505 (Mm), rno:293693 (Rn)
OMIM 613991 (Hs)
Pharos Q6DT37 (Hs)
RefSeq Nucleotide NM_017525 (Hs), XM_140553 (Mm), NM_001130013 (Rn)
RefSeq Protein NP_059995 (Hs), NP_001028514 (Mm), NP_001123485 (Rn)
UniProtKB Q6DT37 (Hs), Q80UW5 (Mm)
Wikipedia CDC42BPG (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: DMPK2
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.4 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.7 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.9 pKd
doramapimod Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.9 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 5.7 pKd
vandetanib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.7 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

GEK subfamily: CDC42 binding protein kinase gamma. Last modified on 29/01/2016. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1506.