Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	288	22q12.3	HMOX1	heme oxygenase 1
Mouse	-	289	8 C1	Hmox1	heme oxygenase 1
Rat	-	289	19p11	Hmox1	heme oxygenase 1

Previous and Unofficial Names

hsp32 | heme oxygenase 1 | Heox | HEOXG | Hmox | HO-1 | heme oxygenase (decycling) 1

Database Links
Alphafold	P09601 (Hs), P14901 (Mm), P06762 (Rn)
BRENDA	1.14.14.18
CATH/Gene3D	1.20.910.10
ChEMBL Target	CHEMBL2823 (Hs), CHEMBL4434 (Mm), CHEMBL5035 (Rn)
Ensembl Gene	ENSG00000100292 (Hs), ENSMUSG00000005413 (Mm), ENSRNOG00000014117 (Rn)
Entrez Gene	3162 (Hs), 15368 (Mm), 24451 (Rn)
Human Protein Atlas	ENSG00000100292 (Hs)
KEGG Enzyme	1.14.14.18
KEGG Gene	hsa:3162 (Hs), mmu:15368 (Mm), rno:24451 (Rn)
OMIM	141250 (Hs)
Pharos	P09601 (Hs)
UniProtKB	P09601 (Hs), P14901 (Mm), P06762 (Rn)
Wikipedia	HMOX1 (Hs)

Enzyme Reaction
EC Number: 1.14.14.18 Description Reaction Reference Protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H(2)O

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 1 [PMID: 16821802] Hs Inhibition 5.8 pKi 4 ⤷ pKi 5.8 (Ki 1.5x10-6 M) [4] Description: Enzyme isolated from human spleen. compound 1 [PMID: 16821802] Rn Inhibition 6.1 pIC50 4 ⤷ pIC50 6.1 (IC50 8x10-7 M) [4] Description: Enzyme isolated from rat spleen.
View species-specific inhibitor tables

Immunopharmacology Comments

Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO). Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation. HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [2]). HO1 may also be involved in macrophage differentiation and polarization to certain subtypes, and studies in animals and in human aortic endothelial cells suggest a protective role in prevention of allograft rejection [1,3].

Cell Type Associations

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   immature conventional dendritic cell (CL:0000840) Comment:  HO1 expression inhibits dendritic cell maturation and secretion of proinflammatory cytokines. References:  2

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) monocyte (CL:0000576) References:  2

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0002246 wound healing involved in inflammatory response IMP GO:0002686 negative regulation of leukocyte migration TAS click arrow to show/hide IEA associations GO:0043305 negative regulation of mast cell degranulation IEA

Immuno Process:  Antigen presentation GO Annotations:  Associated to 1 GO processes GO:0034383 low-density lipoprotein particle clearance TAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002686 negative regulation of leukocyte migration TAS GO:0034101 erythrocyte homeostasis IMP click arrow to show/hide IEA associations GO:0032764 negative regulation of mast cell cytokine production IEA GO:0043305 negative regulation of mast cell degranulation IEA

Immuno Process:  Tissue repair GO Annotations:  Associated to 1 GO processes GO:0002246 wound healing involved in inflammatory response IMP

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0032722 positive regulation of chemokine production TAS click arrow to show/hide IEA associations GO:0032764 negative regulation of mast cell cytokine production IEA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 2 GO processes GO:0002686 negative regulation of leukocyte migration TAS GO:0032722 positive regulation of chemokine production TAS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0043305 negative regulation of mast cell degranulation IEA