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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1265 | 16q24.1 | PLCG2 | phospholipase C gamma 2 | |
Mouse | - | 1265 | 8 64.26 cM | Plcg2 | phospholipase C, gamma 2 | |
Rat | - | 1265 | 19q12 | Plcg2 | phospholipase C, gamma 2 |
Database Links | |
Alphafold | P16885 (Hs), Q8CIH5 (Mm), P24135 (Rn) |
BRENDA | 3.1.4.11 |
CATH/Gene3D | 2.60.40.150, 3.20.20.190, 2.30.29.30 |
ChEMBL Target | CHEMBL4100 (Hs), CHEMBL3608199 (Mm), CHEMBL5230 (Rn) |
Ensembl Gene | ENSG00000197943 (Hs), ENSMUSG00000034330 (Mm), ENSRNOG00000051986 (Rn) |
Entrez Gene | 5336 (Hs), 234779 (Mm), 29337 (Rn) |
Human Protein Atlas | ENSG00000197943 (Hs) |
KEGG Enzyme | 3.1.4.11 |
KEGG Gene | hsa:5336 (Hs), mmu:234779 (Mm), rno:29337 (Rn) |
OMIM | 600220 (Hs) |
Pharos | P16885 (Hs) |
RefSeq Nucleotide | NM_002661 (Hs) |
RefSeq Protein | NP_002652 (Hs) |
UniProtKB | P16885 (Hs), Q8CIH5 (Mm), P24135 (Rn) |
Wikipedia | PLCG2 (Hs) |
Enzyme Reaction | ||||
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Cofactors | ||||||||
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Endogenous activators (Human) |
PIP3, Rac1 (RAC1, P63000), Rac2 (RAC2, P15153), Rac3 (RAC3, P60763) [1,3,7] |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,5], although PLCγ1 may be the predominant isoform active in human mast cells [6]. |
Cell Type Associations | ||||
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Immuno Process Associations | ||
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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]
2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]
3. Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. (2005) Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem, 280 (47): 38923-31. [PMID:16172125]
4. Reynisson J, Court W, O'Neill C, Day J, Patterson L, McDonald E, Workman P, Katan M, Eccles SA. (2009) The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem, 17 (8): 3169-76. [PMID:19303309]
5. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]
6. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]
7. Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P et al.. (2008) rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem, 283 (44): 30351-62. [PMID:18728011]
Phosphoinositide-specific phospholipase C: PLCγ2. Last modified on 14/02/2017. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1408.