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CYP26A1

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Target id: 1366

Nomenclature: CYP26A1

Family: CYP24, CYP26 and CYP27 families

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 497 10q23.33 CYP26A1 cytochrome P450 family 26 subfamily A member 1
Mouse - 497 19 C2 Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1
Rat - - Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1
Previous and Unofficial Names Click here for help
retinoic acid 4-hydroxylase | cytochrome P450, 26, retinoic acid | retinoic acid hydroxylase | cytochrome P450, family 26, subfamily A, polypeptide 1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | cytochrome P450
Database Links Click here for help
Alphafold O43174 (Hs), O55127 (Mm)
BRENDA 1.14.-.-
ChEMBL Target CHEMBL5141 (Hs)
Ensembl Gene ENSG00000095596 (Hs), ENSMUSG00000024987 (Mm), ENSRNOG00000016750 (Rn)
Entrez Gene 1592 (Hs), 13082 (Mm), 154985 (Rn)
Human Protein Atlas ENSG00000095596 (Hs)
KEGG Enzyme 1.14.-.-
KEGG Gene hsa:1592 (Hs), mmu:13082 (Mm), rno:154985 (Rn)
OMIM 602239 (Hs)
Pharos O43174 (Hs)
UniProtKB O43174 (Hs), O55127 (Mm)
Wikipedia CYP26A1 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.-.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5 [PMID: 21838328] Small molecule or natural product Primary target of this compound Hs Inhibition 9.5 pIC50 1
⤷ pIC50 9.5 (IC50 3.5x10-10 M) [1]
Description: Measuring retinoic acid metabolism in a cell-free microsomal assay.
R116010 Small molecule or natural product Hs Inhibition 8.4 pIC50 2
⤷ pIC50 8.4 [2]
liarozole Small molecule or natural product Hs Inhibition 5.7 pIC50 2
⤷ pIC50 5.7 [2]
talarozole Small molecule or natural product Hs Inhibition - - 2
⤷ [2]

References

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1. Gomaa MS, Bridgens CE, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C. (2011) Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). J Med Chem, 54 (19): 6803-11. [PMID:21838328]

2. Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, Isoherranen N. (2011) Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. Mol Pharmacol, 80 (2): 228-39. [PMID:21521770]

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