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Acetyl-CoA carboxylase 2

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Target id: 1264

Nomenclature: Acetyl-CoA carboxylase 2

Abbreviated Name: ACC2

Family: Carboxylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2458 12q24.11 ACACB acetyl-CoA carboxylase beta
Mouse - - Acacb acetyl-Coenzyme A carboxylase beta
Rat - - Acacb acetyl-CoA carboxylase beta
Previous and Unofficial Names Click here for help
ACACB | ACCβ | ACCB | acetyl-Coenzyme A carboxylase beta | acetyl-CoA carboxylase beta | acetyl-Coenzyme A carboxylase 2
Database Links Click here for help
Alphafold O00763 (Hs)
BRENDA 6.4.1.2
CATH/Gene3D 3.30.1490.20
ChEMBL Target CHEMBL4829 (Hs)
Ensembl Gene ENSG00000076555 (Hs), ENSMUSG00000042010 (Mm), ENSRNOG00000000658 (Rn)
Entrez Gene 32 (Hs), 100705 (Mm), 116719 (Rn)
Human Protein Atlas ENSG00000076555 (Hs)
KEGG Enzyme 6.4.1.2
KEGG Gene hsa:32 (Hs), mmu:100705 (Mm), rno:116719 (Rn)
OMIM 601557 (Hs)
Pharos O00763 (Hs)
UniProtKB O00763 (Hs)
Wikipedia ACACB (Hs)
Enzyme Reaction Click here for help
EC Number: 6.4.1.2
Products Click here for help
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2e [PMID: 31900320] Small molecule or natural product Hs Inhibition 8.7 pIC50 6
⤷ pIC50 8.7 (IC50 1.9x10-9 M) [6]
compound 21 [PMID: 23981033] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.4 pIC50 3
⤷ pIC50 8.4 (IC50 4x10-9 M) [3]
A-908292 Small molecule or natural product Hs Inhibition 7.6 pIC50 7
⤷ pIC50 7.6 (IC50 2.3x10-8 M) [7]
clesacostat Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.6 pIC50 5
⤷ pIC50 7.6 (IC50 2.512x10-8 M) [5]
CP-640186 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.4 pIC50 2
⤷ pIC50 7.4 (IC50 3.8x10-8 M) [2]
CP-640186 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 7.2 pIC50 1
⤷ pIC50 7.2 (IC50 6.1x10-8 M) [1]
TOFA Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.9 pIC50 8
⤷ pIC50 4.9 (IC50 1.23x10-5 M) [8]
View species-specific inhibitor tables
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Small molecule or natural product Click here for species-specific activity table Hs Negative 8.2 pIC50 4
⤷ pIC50 8.2 (IC50 6.1x10-9 M) [4]

References

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1. Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. (2009) (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett, 19 (23): 6645-8. [PMID:19853443]

2. Clark RF, Zhang T, Xin Z, Liu G, Wang Y, Hansen TM, Wang X, Wang R, Zhang X, Frevert EU et al.. (2006) Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity. Bioorg Med Chem Lett, 16 (23): 6078-81. [PMID:16973360]

3. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J Med Chem, 56 (17): 7110-9. [PMID:23981033]

4. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci USA, 113 (13): E1796-805. [PMID:26976583]

5. Huard K, Smith AC, Cappon G, Dow RL, Edmonds DJ, El-Kattan A, Esler WP, Fernando DP, Griffith DA, Kalgutkar AS et al.. (2020) Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. J Med Chem, 63 (19): 10879-10896. [PMID:32809824]

6. Takagi H, Tanimoto K, Shimazaki A, Tonomura Y, Momosaki S, Sakamoto S, Abe K, Notoya M, Yukioka H. (2020) A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J Pharmacol Exp Ther, 372 (3): 256-263. [PMID:31900320]

7. Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A et al.. (2008) Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther, 324 (2): 507-16. [PMID:18025247]

8. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res, 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 2. Last modified on 09/11/2022. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1264.