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Fatty acid transport protein 1
Target id: 1108
Nomenclature: Fatty acid transport protein 1
Abbreviated Name: FATP1
Systematic Nomenclature: SLC27A1
Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 646 | 19p13.11 | SLC27A1 | solute carrier family 27 member 1 | |
| Mouse | 1 | 646 | 8 B3.3 | Slc27a1 | solute carrier family 27 (fatty acid transporter), member 1 | |
| Rat | 1 | 646 | 16p14 | Slc27a1 | solute carrier family 27 member 1 | |
| Previous and Unofficial Names |
| Long-chain fatty acid transport protein 1 | solute carrier family 27 member 1 | ACSVL5 | FATP | solute carrier family 27 (fatty acid transporter), member 1 | solute carrier family 27 (fatty acid transporter) |
| Database Links |
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| Specialist databases | |
| Bioparadigms SLC Tables | SLC27A1 (Hs) |
| RESOLUTE | SLC27A1 (Hs) |
| Other databases | |
| Alphafold | Q6PCB7 (Hs), Q60714 (Mm), P97849 (Rn) |
| ChEMBL Target | CHEMBL2052038 (Hs), CHEMBL2052039 (Mm) |
| Ensembl Gene | ENSG00000130304 (Hs), ENSMUSG00000031808 (Mm), ENSRNOG00000018170 (Rn) |
| Entrez Gene | 376497 (Hs), 26457 (Mm), 94172 (Rn) |
| Human Protein Atlas | ENSG00000130304 (Hs) |
| KEGG Gene | hsa:376497 (Hs), mmu:26457 (Mm), rno:94172 (Rn) |
| OMIM | 600691 (Hs) |
| Pharos | Q6PCB7 (Hs) |
| UniProtKB | Q6PCB7 (Hs), Q60714 (Mm), P97849 (Rn) |
| Wikipedia | SLC27A1 (Hs) |
| Endogenous substrates (Human) |
| arachidonic acid > palmitic acid > oleic acid > butyric acid [3] |
| Endogenous substrates (Human) |
| palmitic acid > oleic acid > γ-linolenic acid > octanoic acid [1] |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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References
1. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A. (2003) Characterization of a heart-specific fatty acid transport protein. J Biol Chem, 278 (18): 16039-44. [PMID:12556534]
2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett, 23 (9): 2560-5. [PMID:23528296]
3. Schaffer JE, Lodish HF. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell, 79 (3): 427-36. [PMID:7954810]
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