5-LOX activating protein   Click here for help

GtoPdb Ligand ID: 5183

Abbreviated name: FLAP
Synonyms: 5-lipoxygenase-activating protein | arachidonate 5-lipoxygenase-activating protein
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: FLAP is a scaffolding protein involved in leukotriene (eicosanoid proinflammatory mediator) biosynthesis. It has been investigated as a molecular target for novel anti-inflammatory drugs [3,5], in particular for airway inflammation [4,6].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
5-lipoxygenase-activating protein | arachidonate 5-lipoxygenase-activating protein
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ALOX5AP arachidonate 5-lipoxygenase activating protein Human prepro-arachidonate 5-lipoxygenase-activating protein arachidonate 5-lipoxygenase-activating protein, five-lipoxygenase activating protein, FLAP, MK-886-binding protein
Database Links Click here for help
CATH/Gene3D 1.20.120.550
Ensembl Gene ENSG00000132965 (Hs)
GtoPdb PubChem SID 178101873
Human Protein Atlas ENSG00000132965 (Hs)
UniProtKB P20292 (Hs)
Wikipedia 5-lipoxygenase_activating_protein