quisovalimab   Click here for help

GtoPdb Ligand ID: 11774

Synonyms: AEVI-002 | AVTX-002 | CERC-002 | MDGN-002 | SAR-252067 | SAR252067 [3]
Compound class: Antibody
Comment: Quisovalimab (AVTX-002) is a clinical stage, fully human IgG4 anti-LIGHT (TNFSF14) monoclonal antibody. It was developed for anti-inflammatory potential [3]. Quisovalimab binds to LIGHT and prevents it from interacting with its receptors on T cells [1].
As CERC-002, this agent was assessed for efficacy as a treament for COVID-19-related pneumonia and ARDS/acute lung injury, based on evidence of a pro-inflammatory effect of LIGHT on the interaction between T cells and airway smooth muscle cells [2].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
12100 quisovalimab
Synonyms Click here for help
AEVI-002 | AVTX-002 | CERC-002 | MDGN-002 | SAR-252067 | SAR252067 [3]
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1221
Other databases
GtoPdb PubChem SID 458923809
Search PubMed clinical trials quisovalimab
Search PubMed titles quisovalimab
Search PubMed titles/abstracts quisovalimab