efineptakin alfa   Click here for help

GtoPdb Ligand ID: 11097

Synonyms: GX-I7 | Hyleukin-7 | Il-7 hybrid Fc | NT-I7 | rhIL-7-hyFc | TJ-107
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: Efineptakin alfa is a long-acting immunoglobulin (Ig) fusion protein composed of recombinant human IL-7 fused to a hybrid Fc (hyFc) region of a human antibody. It comprises two disulphide bond-linked peptide chains. Efineptakin alfa has hematopoietic and immunopotentiating activities. In the oncology setting IL-7 enhances T-cell-mediated anti-tumour immune responses. Efineptakin alfa is being developed by Genexine (in-licensed to I-MAB Biopharma) and NeoImmuneTech. The peptide sequence of efineptakin alfa is claimed in Genexine's patent WO2016200219A1 as sequence 24 and would appear to be referred to as MGM-IL-7-hyFc therein [3].
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
10725 efineptakin alfa
Synonyms Click here for help
GX-I7 | Hyleukin-7 | Il-7 hybrid Fc | NT-I7 | rhIL-7-hyFc | TJ-107
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 820
Other databases
CAS Registry No. 2026634-47-7 (source: WHO INN record)
GtoPdb PubChem SID 434122158
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