JV-1-37   Click here for help

GtoPdb Ligand ID: 1108

Compound class: Peptide or derivative
Comment: A synthetic analogue of GHRH
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
YRDAIFTNRYRKVLXQLSARKLLQDIXRR
(indol-3-acetic acid)-Tyr-D-Arg-Asp-Ala-Ile-pCpa-Thr-Asn-Arg-Tyr-Arg-Lys-Val-Leu-Abu-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Nle-D-Arg-Har-NH2
Chemical Modification
N-terminal tyrosine residue is indol-3-acetic acid-tyrosine; residue 2 is D-Arg; residue 6 is para-chlorophenylalanine (pCpa); serine residue 9 of GHRH is substituted for arginine; residue 15 is 2-aminobutanoic acid; residue 27 is norleucine; C-terminal arginine residue is homoarginine-amide