CXCL122 (dimer)   Click here for help

GtoPdb Ligand ID: 8535

Compound class: Peptide or derivative
Comment: A constitutive dimer of human CXCL12α carrying two cysteine substitutions (L36C and A65C) promoting the formation of trans-peptide disulphide bonds which lock the dimer structure [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB. (2011)
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.
Proc Natl Acad Sci USA, 108 (43): 17655-60. [PMID:21990345]
2. Veldkamp CT, Seibert C, Peterson FC, De la Cruz NB, Haugner 3rd JC, Basnet H, Sakmar TP, Volkman BF. (2008)
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12.
Sci Signal, 1 (37): ra4. [PMID:18799424]