MM54   Click here for help

GtoPdb Ligand ID: 6186

Synonyms: cyclo(1-6)CRPRLC-KH-cyclo(9-14)CRPRLC
Compound class: Peptide or derivative
Comment: MM54 is an apelin receptor antagonist. It has been to suppress tumour growth and increase survival in an intracranial xenograft mouse model of glioblastoma [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D et al.. (2017)
Pharmacological targeting of apelin impairs glioblastoma growth.
Brain, 140 (11): 2939-2954. [PMID:29053791]
2. Macaluso NJ, Pitkin SL, Maguire JJ, Davenport AP, Glen RC. (2011)
Discovery of a competitive apelin receptor (APJ) antagonist.
ChemMedChem, 6 (6): 1017-23. [PMID:21560248]