YSFKPMPLaR   Click here for help

GtoPdb Ligand ID: 5776

Synonyms: C5a65-74Y65,F67,P69,P71,D-Ala73
Compound class: Peptide or derivative
Comment: Synthetic analogue of human C5a
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Finch AM, Vogen SM, Sherman SA, Kirnarsky L, Taylor SM, Sanderson SD. (1997)
Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity.
J Med Chem, 40 (6): 877-84. [PMID:9083476]
2. Scully CC, Blakeney JS, Singh R, Hoang HN, Abbenante G, Reid RC, Fairlie DP. (2010)
Selective hexapeptide agonists and antagonists for human complement C3a receptor.
J Med Chem, 53 (13): 4938-48. [PMID:20527893]
3. Woodruff TM, Strachan AJ, Sanderson SD, Monk PN, Wong AK, Fairlie DP, Taylor SM. (2001)
Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes.
Inflammation, 25 (3): 171-7. [PMID:11403208]