APETx-1   Click here for help

GtoPdb Ligand ID: 2609

Synonyms: Toxin APETx1
Compound class: Peptide or derivative
Comment: From Anthopleura elegantissima (Sea anemone)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Diochot S, Loret E, Bruhn T, Béress L, Lazdunski M. (2003)
APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels.
Mol Pharmacol, 64 (1): 59-69. [PMID:12815161]
2. Zhang M, Liu XS, Diochot S, Lazdunski M, Tseng GN. (2007)
APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go- related potassium channel.
Mol Pharmacol, 72 (2): 259-68. [PMID:17473056]