peptide YY   Click here for help

GtoPdb Ligand ID: 1514

Abbreviated name: PYY
Synonyms: peptide tyrosine tyrosine
Compound class: Endogenous peptide in human, mouse or rat
Comment: Peptide YY is a neuropeptide Y2 receptor agonist. It has been investigated as a potential appetite suppressant [2,6,8-9].
Species: Human
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: peptide yy

References
1. Dumont Y, Quirion R. (2000)
[(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.
Br J Pharmacol, 129 (1): 37-46. [PMID:10694200]
2. Fazen CH, Valentin D, Fairchild TJ, Doyle RP. (2011)
Oral delivery of the appetite suppressing peptide hPYY(3-36) through the vitamin B12 uptake pathway.
J Med Chem, 54 (24): 8707-11. [PMID:22054008]
3. Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA. (1996)
Expression cloning of a human brain neuropeptide Y Y2 receptor.
Mol Pharmacol, 49 (2): 224-8. [PMID:8632753]
4. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL. (1995)
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.
J Biol Chem, 270 (45): 26758-61. [PMID:7592910]
5. Krause J, Eva C, Seeburg PH, Sprengel R. (1992)
Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor.
Mol Pharmacol, 41 (5): 817-21. [PMID:1316999]
6. Kuehl PJ, Boyden T, Dobry DE, Doyle-Eisele M, Friesen DT, McDonald JD, Murri BG, Vodak DT, Lyon DK. (2016)
Inhaled PYY(3-36) dry-powder formulation for appetite suppression.
Drug Dev Ind Pharm, 42 (1): 150-156. [PMID:26006332]
7. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D. (1995)
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
J Biol Chem, 270 (49): 29123-8. [PMID:7493937]
8. Nadkarni PP, Costanzo RM, Sakagami M. (2011)
Pulmonary delivery of peptide YY for food intake suppression and reduced body weight gain in rats.
Diabetes Obes Metab, 13 (5): 408-17. [PMID:21226821]
9. Steinert RE, Poller B, Castelli MC, Drewe J, Beglinger C. (2010)
Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects.
Am J Clin Nutr, 92 (4): 810-7. [PMID:20720259]
10. Toräng S, Veedfald S, Rosenkilde MM, Hartmann B, Holst JJ. (2015)
The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo.
Physiol Rep, 3 (7). [PMID:26197931]
11. Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA. (1997)
A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Peptides, 18 (4): 609-12. [PMID:9210181]