Synonyms: ARV-471 | ARV471 | compound 341 [WO2018102725A1]
Compound class:
Synthetic organic
Comment: Vepdegrestrant (ARV471) is a bifunctional compound that is estrogen receptor (ER) degrader (PROTAC) [1]. It uses a cereblon-based binder to direct ER protein degradation. ARV471 is being investigated for potential to treat breast cancer.
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References |
1. Crew AP, Qian Y, Dong H, Wang J, Hornberger KR, Crews CM. (2018)
Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders. Patent number: WO2018102725A1. Assignee: Arvinas Inc.. Priority date: 01/12/2016. Publication date: 07/06/2018. |