osocimab   Click here for help

GtoPdb Ligand ID: 11366

Synonyms: BAY 1213790 | BAY-1213790 | BAY1213790
Compound class: Antibody
Comment: Osocimab (BAY 1213790) is a fully humanized monoclonal antibody that targets activated Factor XI [1]. It is being investigated for clinical prevention of thrombosis [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Schaefer M, Buchmueller A, Dittmer F, Straßburger J, Wilmen A. (2019)
Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.
J Mol Biol, 431 (24): 4817-4833. [PMID:31655039]
2. Weitz JI, Bauersachs R, Becker B, Berkowitz SD, Freitas MCS, Lassen MR, Metzig C, Raskob GE. (2020)
Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty: The FOXTROT Randomized Clinical Trial.
JAMA, 323 (2): 130-139. [PMID:31935028]