muromonab-CD3   Click here for help

GtoPdb Ligand ID: 6889

Synonyms: L04AA02 | OKT-3 | Orthoclone Okt3®
Approved drug Immunopharmacology Ligand
muromonab-CD3 is an approved drug (FDA (1992))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Immunopharmacology Comments
Muromonab-CD3 binds to CD3 on T cells and induces Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
Immunopharmacology Disease
Disease X-Refs Comment References
Allograft rejection Approved to prevent renal, cardiac and hepatic allograft rejection. Withdrawn from the US market.