Immunopharmacology Comments

The Fas ligand (CD95L)/Fas receptor (CD95) interaction generates a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. This system is also important in the immune elimination of virus-infected cells, cancer cells and autoreactive T cells. Mouse strains with mutations in Fas or CD95L develop lymphoproliferative conditions, indicating the importance of these proteins to immune cell homeostasis [2]. Fas or CD95L knockout mice show a more severe autoimmune phenotype than the mutant mice mentioned. Humans with type 1a and 1b autoimmune lymphoproliferative syndrome (ALPS) carry mutations in Fas and CD95L respectively.

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Autoimmune lymphoproliferative syndrome; ALPS	Disease Ontology: DOID:6688 OMIM: 601859 Orphanet: ORPHA3261	Type 1b ALPS is caused by mutation of CD95L (Fas ligand).	1