bumetanide   Click here for help

GtoPdb Ligand ID: 4837

Synonyms: Bumex® | Burinex® | PF 1593 | Ro 10-6338
Approved drug PDB Ligand
bumetanide is an approved drug (FDA (1983))
Compound class: Synthetic organic
Comment: Bumetanide is a loop diuretic drug. It inhibits NKCC1 (SLC12A2) tranporters in the brain and kidney-specific NKCC2 (SLC12A1) transporters in the thick ascending limb of Henle's loop. The latter action modulates water and electrolyte homeostasis and is reponsible for the drug's diuretic effects.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: bumetanide

bumetanide is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 127.1
Molecular weight 364.11
XLogP 2.57
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O
Isomeric SMILES CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O
InChI InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChI Key MAEIEVLCKWDQJH-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
A loop diuretic use to treat edema associated with heart failure, hepatic and renal disease.

Diuretics and autism spectrum disorder (ASD)
Treatment of autistic children and adolescents with bumetanide (Phase 3 trial NCT01078714) improves core ASD symptoms [2-3]. The mechanism is proposed (at least in part) to reflect the effect that bumetanide exerts on intracellular neuronal chloride levels and the consequences of this on GABAergic networks. In preclinical models bumetanide decreases interacellular chloride levels and promotes GABAergic mediated hyperpolarisation (inhibition).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Bumetanide appears to cause altered electrolyte transfer in the proximal tubule of the kidney. This results in renal excretion of sodium, chloride, and water and, hence, diuresis.