Synonyms: ARV-471 | ARV471 | compound 341 [WO2018102725A1]
Compound class:
Synthetic organic
Comment: Vepdegrestrant (ARV471) is a bifunctional compound that is estrogen receptor (ER) degrader (PROTAC) [1]. It uses a cereblon-based binder to direct ER protein degradation. ARV471 is being investigated for potential to treat breast cancer.
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No information available. |
Summary of Clinical Use |
The first study to evaluate ARV471 for ER+/HER2- locally advanced or metastatic breast cancer is comparing it as a monotherapy vs. in combination with the CDK4/6 kinase inhibitor palbociclib. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT04072952 | A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer | Phase 1/Phase 2 Interventional | Arvinas Inc |