Synonyms: CD37-SMIP [8] | TRU-016 | TRU016
Compound class:
Antibody
Comment: Otlertuzumab (TRU-016) is a monospecific, humanized anti-CD37 antibody-like protein that is being investigated as a clinical therapeutic for various form of lymphoma [4,6-7]. Otlertuzumab was developed using Aptevo's modular ADAPTIRTM platform.
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Bioactivity Comments |
Rafiq et al. (2013) [5] show a dose-respnse curve of TRU-016 binding to CD37 on Daudi cells (with the x axis labeled as 'ng/well' rather than as a defined molarity), but do not present a calculated affinity constant. |
Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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