CEP-1347   Click here for help

GtoPdb Ligand ID: 8173

Synonyms: CEP 1347 | CEP1347 | KT-7515 | KT7515 [5]
Compound class: Synthetic organic
Comment: CEP-1347 is a semi-synthetic analogue of the natural alkaloid K-252a [5]. CEP-1347 was originally identified as a pan-mixed lineage kinase (MLK) family inhibitor [8]. In this setting it inhibits downstream c-jun N-terminal kinase (JNK) activation and has neuroprotective activity [1-2,7].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 145.32
Molecular weight 615.19
XLogP 7.52
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCSCc1ccc2c(c1)c1c3C(=O)NCc3c3c4c1n2C1CC(C(O1)(n4c1c3cc(cc1)CSCC)C)(O)C(=O)OC
Isomeric SMILES CCSCc1ccc2c(c1)c1c3C(=O)NCc3c3c4c1n2[C@H]1C[C@]([C@](O1)(n4c1c3cc(cc1)CSCC)C)(O)C(=O)OC
InChI InChI=1S/C33H33N3O5S2/c1-5-42-15-17-7-9-22-19(11-17)26-27-21(14-34-30(27)37)25-20-12-18(16-43-6-2)8-10-23(20)36-29(25)28(26)35(22)24-13-33(39,31(38)40-4)32(36,3)41-24/h7-12,24,39H,5-6,13-16H2,1-4H3,(H,34,37)/t24-,32+,33+/m1/s1
InChI Key SCMLRESZJCKCTC-KMYQRJGFSA-N
Bioactivity Comments
CEP-1347 is often descrided as a selective inhibitor of mitogen-activated protein kinase kinase kinase 11 (MLK3), but in fact has inhibitory activity (> 99% inhibition) across all MLKs and a range of additional kinases [3]. The off-targets include leucine-rich repeat kinase 2 (LRRK2), fms-related tyrosine kinase 3 (FLT3), calcium/calmodulin-dependent protein kinase ID (CAMK1D), c-kit receptor tyrosine kinase (KIT) and Aurora kinases A and C [3].
We have tagged MLK1 as the primary molecular target for this compound for data metrics proposes only, and fully acknowledge its effect on other targets.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
mitogen-activated protein kinase kinase kinase 9 Primary target of this compound Hs Inhibitor Inhibition 7.4 – 9.0 pIC50 - 3,5,9
⤷ pIC50 7.4 – 9.0 (IC50 3.8x10-8 – 1x10-9 M) [3,5,9]
mitogen-activated protein kinase kinase kinase 10 Hs Inhibitor Inhibition 7.3 – 8.7 pIC50 - 3,5
⤷ pIC50 7.3 – 8.7 (IC50 5.1x10-8 – 2x10-9 M) [3,5]
mitogen-activated protein kinase kinase kinase 11 Hs Inhibitor Inhibition 7.6 – 8.2 pIC50 - 3,5
⤷ pIC50 7.6 – 8.2 (IC50 2.3x10-8 – 6x10-9 M) [3,5]
mitogen-activated protein kinase kinase kinase 12 Hs Inhibitor Inhibition 6.9 pIC50 - 9
⤷ pIC50 6.9 (IC50 1.14x10-7 M) [9]