mepolizumab   Click here for help

GtoPdb Ligand ID: 7685

Synonyms: Nucala® | SB-240563
Approved drug Immunopharmacology Ligand
mepolizumab is an approved drug (EMA & FDA (2015))
Compound class: Antibody
Comment: The Nucala® brand of mepolizumab is a humanized interleukin-5 antagonist monoclonal antibody produced by recombinant DNA technology in Chinese hamster ovary cells.
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Bioactivity Comments
In monkey studies mepolizumab decreased eosinophil count with an IC50 of 1.43 μg/ml, and exhibited a half-life of ~14.5 days [9].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-5 Primary target of this compound Hs Antibody Binding 11.4 pKd - 5
⤷ pKd 11.4 (Kd 4.2x10-12 M) [5]
Description: Binding affinity for recombinant human IL-5.