IFN-γ   Click here for help

GtoPdb Ligand ID: 4968

Synonyms: Actimmune® | immune interferon | interferon gamma
Approved drug Immunopharmacology Ligand
IFN-γ is an approved drug (FDA (1999))
Compound class: Endogenous peptide in human, mouse or rat
Comment: IFN-γ is a type II interferon. It is biologically active as a homodimer.
Species: Human
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: interferon-gamma (ifn-γ)

Natural/Endogenous Targets
Target
Interferon-γ receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interferon-γ receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
emapalumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 9.1 pKd - 1
⤷ pKd 9.1 (Kd 7.32x10-10 M) [1]
Description: Measured using Biacore technology
fontolizumab Peptide Primary target of this compound Hs Antibody Binding - - - 2
⤷ [2]