neuropeptide head activator   Click here for help

GtoPdb Ligand ID: 2496

Synonyms: HA
Comment: Originally isolated from the freshwater coelenterate hydra (Hydra attenuata). Although the isolation of a peptide of identical amino acid sequence from human hypothalamus, bovine hypothalamus and rat intestine has been reported, its existence in mammals must be considered unproven because there is no evidence for the presence of a precursor gene for this peptide in any sequenced genome.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR37 Hs Agonist Agonist 8.0 – 8.5 pEC50 - 2
pEC50 8.0 – 8.5 (EC50 1.1x10-8 – 3.3x10-9 M) [2]
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPV2 Mm Activator Agonist - - 2x10-9 1
Conc range: 2x10-9 M [1]
Voltage: -60.0 mV