H2O2   Click here for help

GtoPdb Ligand ID: 2448

Synonyms: hydrogen peroxide
Compound class: Inorganic
Comment: At high concentrations H2O2 is toxic and damages cells, but at low levels it modulates some important physiological processes, including signaling in cell proliferation, apoptosis, carbohydrate metabolism, and platelet activation. Catalase is the main H2O2-degrading enzyme in mammalian cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
thyroid peroxidase 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM2 Ligand is endogenous in the given species Hs Activator Agonist - - 5x10-7 - 5x10-5 2-4,6-7
⤷ Conc range: 5x10-7 - 5x10-5 M [2-4,6-7]
Voltage: Physiological
TRPA1 Ligand is endogenous in the given species Mm Activator Activation 3.6 pEC50 - 1,5
⤷ pEC50 3.6 [1,5]
Description: Calcium imaging
Conditions: CHO cells expressing mouse TRPA1 loaded with Fura-2
Targets where the ligand is described in the comment field
Target Comment
catalase Catalase is a heme-containing enzyme that protects cells from the damaging effects of the reactive oxygen species hydrogen peroxide (H2O2).
Ligand mentioned in the following text fields
Nitric oxide synthases comments