Natural/Endogenous Targets
Target ASIC1 ASIC2 ASIC3 glycine receptor α1 subunit ZAC

Selectivity at ion channels
Key to terms and symbols		Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference Kir2.4 Hs Gating inhibitor (Extracellular H+) Antagonist 7.1 pKi - 3 ⤷ pKi 7.1 [3] Voltage: -120.0 mV Kir2.3 Hs Gating inhibitor (Extracellular H+) Antagonist 6.7 – 7.4 pKi - 1,6,11 ⤷ pKi 6.7 – 7.4 [1,11] Voltage: -120.0 – -100.0 mV pKi 6.8 – 6.8 [6,11] Voltage: -150.0 – 100.0 mV Kir4.2 Rn Gating inhibitor (Intracellular H+) Antagonist 6.7 – 7.1 pEC50 - 5 ⤷ pEC50 6.7 – 7.1 [5] Voltage: -100.0 mV Kir4.1 Rn Gating inhibitor (Intracellular H+) Antagonist 6.0 – 6.1 pEC50 - 5,10 ⤷ pEC50 6.0 – 6.1 [5,10] Voltage: -100.0 mV ASIC1 Hs Activator (Extracellular H+) - ~5.1 – 6.8 pEC50 - ⤷ pEC50 ~6.2 – 6.8 (EC50 ~6.3x10-7 – 1.6x10-7 M) ASIC1a pEC50 ~5.1 – 6.2 (EC50 ~8x10-6 – 6.3x10-7 M) ASIC1b ZAC Hs Agonist Agonist 5.6 pEC50 - 8 ⤷ pEC50 5.6 [8] TRPV1 Hs Activator (extracellular H+) - 5.4 pEC50 - ⤷ pEC50 5.4 (EC50 3.98x10-6 M) at 37°C ASIC3 Hs Activator (Extracellular H+) - ~3.5 – 6.7 pEC50 - ⤷ pEC50 ~6.2 – 6.7 (EC50 ~6.3x10-7 – 2x10-7 M) transient component pEC50 ~3.5 – 4.3 (EC50 ~3.5x10-4 – 5x10-5 M) sustained component ASIC2 Hs Activator (Extracellular H+) - ~4.1 – 5.0 pEC50 - ⤷ pEC50 ~4.1 – 5.0 (EC50 ~8x10-5 – 1x10-5 M) TRPM7 Hs Activator (Extracellular H+) Potentiation 4.5 pEC50 - 4 ⤷ pEC50 4.5 [4] Kir1.1 Rn Gating inhibitor (Intracellular H+) Antagonist 6.8 pIC50 - 2,7,9 ⤷ pIC50 6.8 [2,7,9] Voltage: -160.0 – -40.0 mV TRPM5 Hs Channel blocker (Extracellular H+) - 3.2 pIC50 - ⤷ pIC50 3.2 (IC50 6.3x10-4 M) glycine receptor α1 subunit Hs Allosteric modulator (Extracellular H+) Inhibition - - - ⤷ endogenous TRPC6 Hs Channel blocker (Extracellular H+) - - - - ⤷ TRPM2 Hs Channel blocker (extracellular H+) - - - - ⤷ TRPM6 Hs Activator (extracellular H+) Potentiation - - - ⤷ μM range

Ligand mentioned in the following text fields
ZAC overview