Compound class:
Synthetic organic
Comment: Allosteric modulator of the β2-adrenergic receptor.
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Bioactivity Comments |
AS408 stabilizesan inactive conformation of the β2AR, and acts as a negative allosteric modulator for agonists and positive allosteric modulator for inverse agonists. Therefore, while AS408 is a NAM for agonist binding, G-protein activation and arrestin recruitment, AS408 is a modest PAM for binding to inverse agonists [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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