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iscalimab   Click here for help

GtoPdb Ligand ID: 9802

Synonyms: CFZ-533 | CFZ533 | NVP-CFZ533 | OM11-62MF
Immunopharmacology Ligand
Compound class: Antibody
Comment: Iscalimab (CFZ533) is a Fc-silent anti-CD40 monoclonal antibody that is designed exhibit no agonist activity and is non-depleting (no ADCC activity for an improved safety profile, particularly in non-oncologic indications) [1,8]. It is claimed in Novartis' patent WO2012065950 [6] as mAb1 (based on peptide sequence alignments between the INN record for iscalimab and patented sequences retrieved from a BLAST search). Blocking CD40-mediated inflammatory responses is a well advanced mechanism being expoited for potential to treat autoimmune and inflammatory disorders and/or for preventing/reducing graft rejection following organ transplant.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10707 iscalimab
Synonyms Click here for help
CFZ-533 | CFZ533 | NVP-CFZ533 | OM11-62MF
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 799
Other databases
GtoPdb PubChem SID 354702274
Search PubMed clinical trials iscalimab
Search PubMed titles iscalimab
Search PubMed titles/abstracts iscalimab